ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pez

Alias:

CG9493|PTPD1

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

26C3-26C3

Physical Location:

6332875-6338492 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11099 Symbol (Name): PTPN21 (protein tyrosine phosphatase, non-receptor type 21)

Ortholog Status:

The human GeneID 11099 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pez
P Value:		1.11E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_135169.2	NP_609013.1	NT_033779.4 range: 6332875..6338492, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	ISS
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	NAS (10908587)
GO:0005488	binding	Molecular Function	IEA
GO:0008092	cytoskeletal protein binding	Molecular Function	ISS (10908588)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	NAS (10908587)