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Gene Information
Gene ID:33882
Organism:Drosophila melanogaster (Fly)
Genetic Location:26C3-26C3
Physical Location:6332875-6338492 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 11099    Symbol (Name): PTPN21 (protein tyrosine phosphatase, non-receptor type 21)
Ortholog Status:The human GeneID 11099 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pez
P Value:1.11E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135169.2NP_609013.1NT_033779.4 range: 6332875..6338492, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0004725protein tyrosine phosphatase activityMolecular FunctionISS
GO:0004725protein tyrosine phosphatase activityMolecular FunctionNAS (10908587)
GO:0005488bindingMolecular FunctionIEA
GO:0008092cytoskeletal protein bindingMolecular FunctionISS (10908588)
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessNAS (10908587)
Other Database Cross Links
NCBI Entrez Gene:33882