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Gene Information
Gene ID:33989
Organism:Drosophila melanogaster (Fly)
Genetic Location:27D5-27D5
Physical Location:7032712-7037619 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 9584    Symbol (Name): RBM39 (RNA binding motif protein 39)
Ortholog Status:The human GeneID 9584 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG11266
P Value:1.67E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135251.2NP_609095.1NT_033779.4 range: 7032712..7037619
NM_164730.1NP_723243.1NT_033779.4 range: 7032712..7037619
NM_164731.1NP_723244.2NT_033779.4 range: 7032712..7037619
NM_164732.1NP_723245.1NT_033779.4 range: 7032712..7037619
NM_164733.1NP_723246.1NT_033779.4 range: 7032712..7037619
NM_164734.1NP_723247.1NT_033779.4 range: 7032712..7037619
NM_164735.1NP_723248.1NT_033779.4 range: 7032712..7037619
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIC (15492211)
GO:0005681spliceosomeCellular ComponentISS
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0003729mRNA bindingMolecular FunctionISS (10908586)
GO:0000381regulation of alternative nuclear mRNA splicing, via spliceosomeBiological ProcessIMP (15492211)
GO:0008380RNA splicingBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:33989