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Gene Information
Gene ID:34003
Organism:Drosophila melanogaster (Fly)
Genetic Location:27E4-27E5
Physical Location:7205249-7220028 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 80148    Symbol (Name): PQLC1 (PQ loop repeat containing 1)
Ortholog Status:The human GeneID 80148 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG13784
P Value:4.17E-02
Note:Acute up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001042878.1NP_001036343.1NT_033779.4 range: 7205249..7220028, complement
NM_164742.1NP_723261.1NT_033779.4 range: 7205249..7220028, complement
Other Database Cross Links
NCBI Entrez Gene:34003