ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

34012

Symbol:

ninaC

Alias:

2.2|CG5125|CG54125|CT16120|CT42491|DRONINAC|Dm NinaC|NINA C

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

27F3-27F3

Physical Location:

7377717-7384343 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		ninaC
P Value:		4.32E-02
Note:		Transient down-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078779.2	NP_523503.2	NT_033779.4 range: 7377717..7384343
NM_164747.1	NP_723271.1	NT_033779.4 range: 7377717..7384343

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	NAS
GO:0005737	cytoplasm	Cellular Component	IDA (1569127)
GO:0016027	inaD signaling complex	Cellular Component	TAS (12765677)
GO:0016028	rhabdomere	Cellular Component	IDA (1569127\|2449973)
GO:0016459	myosin complex	Cellular Component	IEA
GO:0016459	myosin complex	Cellular Component	ISS (10908588)
GO:0016461	unconventional myosin complex	Cellular Component	ISS (2449973)
GO:0016461	unconventional myosin complex	Cellular Component	NAS
GO:0042385	myosin III complex	Cellular Component	NAS (10611962)
GO:0035091	phosphoinositide binding	Molecular Function	IDA (15233920)
GO:0042623	ATPase activity, coupled	Molecular Function	ISS (10908588)
GO:0003774	motor activity	Molecular Function	IEA
GO:0004702	receptor signaling protein serine/threonine kinase activity	Molecular Function	NAS (10908587)
GO:0005516	calmodulin binding	Molecular Function	TAS (10611962)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	ISS (2449973)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (8755717)
GO:0004672	protein kinase activity	Molecular Function	ISS (2449973)
GO:0005516	calmodulin binding	Molecular Function	IMP (8235618)
GO:0016062	adaptation of rhodopsin mediated signaling	Biological Process	TAS (9822721\|10611962)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0016062	adaptation of rhodopsin mediated signaling	Biological Process	IMP (9822721\|15233920)
GO:0016059	deactivation of rhodopsin mediated signaling	Biological Process	TAS (9822721\|10611962)
GO:0016059	deactivation of rhodopsin mediated signaling	Biological Process	IMP (9822721)
GO:0008104	protein localization	Biological Process	TAS (10611962)
GO:0008104	protein localization	Biological Process	IMP (8235618)
GO:0007604	phototransduction, UV	Biological Process	IMP
GO:0007010	cytoskeleton organization and biogenesis	Biological Process	IMP (1569127)
GO:0006886	intracellular protein transport	Biological Process	IMP (15233920)
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (10908587)
GO:0007603	phototransduction, visible light	Biological Process	IMP (8235618)