ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG18585

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

28C1-28C1

Physical Location:

7689365-7691056 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1357 Symbol (Name): CPA1 (carboxypeptidase A1 (pancreatic))

Ortholog Status:

The human GeneID 1357 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG18585
P Value:		9.19E-03
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_135288.2	NP_609132.1	NT_033779.4 range: 7689365..7691056, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004182	carboxypeptidase A activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA