Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:34042
Organism:Drosophila melanogaster (Fly)
Genetic Location:28C1-28C1
Physical Location:7691108-7692675 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1357    Symbol (Name): CPA1 (carboxypeptidase A1 (pancreatic))
Ortholog Status:The human GeneID 1357 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG7025
P Value:1.26E-02
Note:Acute down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135289.2NP_609133.2NT_033779.4 range: 7691108..7692675, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004181metallocarboxypeptidase activityMolecular FunctionISS
GO:0004182carboxypeptidase A activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:34042