ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IDH1

Full Name:

isocitrate dehydrogenase 1 (NADP+), soluble

Alias:

IDH|IDP|PICD

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33.3

Physical Location:

208809197-208828050 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15926 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

IDH1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005896.2	NP_005887.2	NC_000002.10 range: 208809197..208828050, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005777	peroxisome	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	TAS (9866202)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0004450	isocitrate dehydrogenase (NADP+) activity	Molecular Function	TAS (9866202)
GO:0004450	isocitrate dehydrogenase (NADP+) activity	Molecular Function	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	TAS (9866202)
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA
GO:0006102	isocitrate metabolic process	Biological Process	TAS (9866202)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006097	glyoxylate cycle	Biological Process	IEA