ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG4364

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

30C5-30C6

Physical Location:

9708919-9711268 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23481 Symbol (Name): PES1 (pescadillo homolog 1, containing BRCT domain (zebrafish))

Ortholog Status:

The human GeneID 23481 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG4364
P Value:		1.55E-02
Note:		Transient up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_135461.2	NP_609305.1	NT_033779.4 range: 9708919..9711268, complement

Gene Ontology (GO) Annotation