ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

mre11

Alias:

CG16928|MRE11

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

32E2-32E2

Physical Location:

11282092-11284336 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4361 Symbol (Name): MRE11A (MRE11 meiotic recombination 11 homolog A (S. cerevisiae))

Ortholog Status:

The human GeneID 4361 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		mre11
P Value:		4.06E-02
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078823.2	NP_523547.1	NT_033779.4 range: 11282092..11284336

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0004519	endonuclease activity	Molecular Function	ISS
GO:0004519	endonuclease activity	Molecular Function	NAS
GO:0004527	exonuclease activity	Molecular Function	ISS
GO:0004527	exonuclease activity	Molecular Function	NAS
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process	IMP (16020777)
GO:0006302	double-strand break repair	Biological Process	ISS
GO:0006289	nucleotide-excision repair	Biological Process	NAS
GO:0000723	telomere maintenance	Biological Process	IMP (15296751\|15296753)
GO:0051276	chromosome organization and biogenesis	Biological Process	IMP (15296751\|15296753)