Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:34569
Symbol:salm
Alias:3602|CG6464|SAL|SPALT|l(2)03602|salII
Organism:Drosophila melanogaster (Fly)
Chromosome:2L
Genetic Location:32F1-32F2
Physical Location:11434310-11445602 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6299    Symbol (Name): SALL1 (sal-like 1 (Drosophila))
Ortholog Status:The human GeneID 6299 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:salm
P Value:2.62E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_164966.2NP_723670.2NT_033779.4 range: 11434310..11445602, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentNAS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionNAS
GO:0030528transcription regulator activityMolecular FunctionNAS
GO:0035277spiracle morphogenesis, open tracheal systemBiological ProcessIMP (10491268)
GO:0045449regulation of transcriptionBiological ProcessNAS
GO:0045465R8 cell differentiationBiological ProcessIMP
GO:0045465R8 cell differentiationBiological ProcessNAS (11880339)
GO:0045466R7 cell differentiationBiological ProcessIMP
GO:0046845branched duct epithelial cell fate determination, open tracheal systemBiological ProcessTAS (10684581|11063940|12791296)
GO:0016481negative regulation of transcriptionBiological ProcessNAS (10684581)
GO:0008586imaginal disc-derived wing vein morphogenesisBiological ProcessTAS (10625531)
GO:0001751compound eye photoreceptor cell differentiationBiological ProcessIMP (11528479)
GO:0007438oenocyte developmentBiological ProcessIMP (11171397)
GO:0007427epithelial cell migration, open tracheal systemBiological ProcessTAS (10943305)
GO:0007424open tracheal system developmentBiological ProcessTAS (10684581|14570584)
GO:0007424open tracheal system developmentBiological ProcessIMP (15620646)
GO:0007423sensory organ developmentBiological ProcessIMP (11171396)
GO:0007379segment specificationBiological ProcessNAS
GO:0048098antennal joint developmentBiological ProcessIMP (11934862)
Other Database Cross Links
NCBI Entrez Gene:34569
FLYBASE:FBgn0004579