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Gene Information
Gene ID:34686
Symbol:MRP
Alias:CG6214|dMRP|dMRP/CG6214
Organism:Drosophila melanogaster (Fly)
Chromosome:2L
Genetic Location:33F3-33F4
Physical Location:12719070-12744808 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 4363    Symbol (Name): ABCC1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1)
Ortholog Status:The human GeneID 4363 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG6214
P Value:2.02E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135747.3NP_609591.2NT_033779.4 range: 12719070..12744808
NM_165020.2NP_723772.2NT_033779.4 range: 12719070..12744808
NM_205968.1NP_995690.1NT_033779.4 range: 12719070..12744808
NM_205969.1NP_995691.1NT_033779.4 range: 12719070..12744808
NM_205970.1NP_995692.1NT_033779.4 range: 12719070..12744808
NM_205971.1NP_995693.1NT_033779.4 range: 12719070..12744808
NM_205972.1NP_995694.1NT_033779.4 range: 12719070..12744808
NM_205973.1NP_995695.1NT_033779.4 range: 12719070..12744808
NM_205974.1NP_995696.1NT_033779.4 range: 12719070..12744808
NM_205975.1NP_995697.1NT_033779.4 range: 12719070..12744808
NM_205976.1NP_995698.1NT_033779.4 range: 12719070..12744808
NM_205977.1NP_995699.1NT_033779.4 range: 12719070..12744808
NM_205978.1NP_995700.1NT_033779.4 range: 12719070..12744808
NM_205979.1NP_995701.1NT_033779.4 range: 12719070..12744808
NM_205980.1NP_995702.1NT_033779.4 range: 12719070..12744808
NM_205981.1NP_995703.1NT_033779.4 range: 12719070..12744808
NM_205982.1NP_995704.1NT_033779.4 range: 12719070..12744808
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0008559xenobiotic-transporting ATPase activityMolecular FunctionISS
GO:0042626ATPase activity, coupled to transmembrane movement of substancesMolecular FunctionIDA
GO:0043492ATPase activity, coupled to movement of substancesMolecular FunctionIDA (15373810)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:34686
FLYBASE:FBgn0032456