ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IGF1R

Full Name:

insulin-like growth factor 1 receptor

Alias:

CD221|IGFIR|JTK13|MGC142170|MGC142172|MGC18216

Organism:

Homo sapiens (Human)

Chromosome:

15

Genetic Location:

15q26.3

Physical Location:

97010283-97325281 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

X04434

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

IGF1R

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000875.3	NP_000866.1	NC_000015.8 range: 97010283..97325281

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IC (7679099)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (11448933)
GO:0043548	phosphoinositide 3-kinase binding	Molecular Function	IPI (7541045)
GO:0043560	insulin receptor substrate binding	Molecular Function	IPI (7541045)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005520	insulin-like growth factor binding	Molecular Function	IDA (1846292\|7679099)
GO:0005010	insulin-like growth factor receptor activity	Molecular Function	IDA (7679099)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (1846292\|7679099\|11162456)
GO:0048009	insulin-like growth factor receptor signaling pathway	Biological Process	IDA (7679099)
GO:0008286	insulin receptor signaling pathway	Biological Process	TAS (10829031)
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (10749889)
GO:0007165	signal transduction	Biological Process	TAS (3003744)
GO:0006916	anti-apoptosis	Biological Process	TAS (8710868)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0051262	protein tetramerization	Biological Process	IDA (1846292)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000140443

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: