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Gene Information
Gene ID:351
Full Name:amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
Organism:Homo sapiens (Human)
Genetic Location:21q21.2|21q21.3
Physical Location:26174731-26465002 on NC_000021.7, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 54226 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:APP
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original ID1:BM841483
Fold Change:0.57
P Value:5.00E-03
Tissue:Nucleus accumbens
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000484.2NP_000475.1NC_000021.7 range: 26174731..26465002, complement
NM_201413.1NP_958816.1NC_000021.7 range: 26174731..26465002, complement
NM_201414.1NP_958817.1NC_000021.7 range: 26174731..26465002, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0009986cell surfaceCellular ComponentIDA (7593229)
GO:0031093platelet alpha granule lumenCellular ComponentEXP (2110384)
GO:0005905coated pitCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (10806211)
GO:0005576extracellular regionCellular ComponentTAS (10806211)
GO:0005576extracellular regionCellular ComponentEXP (2110384)
GO:0016020membraneCellular ComponentIEA
GO:0008201heparin bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0033130acetylcholine receptor bindingMolecular FunctionIPI (10681545)
GO:0042802identical protein bindingMolecular FunctionIPI (16286452)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005507copper ion bindingMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionNAS (11279603)
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionIDA (10652580)
GO:0007219Notch signaling pathwayBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessIEA
GO:0006915apoptosisBiological ProcessIEA
GO:0006897endocytosisBiological ProcessIEA
GO:0006878cellular copper ion homeostasisBiological ProcessTAS (15910549)
GO:0050905neuromuscular processBiological ProcessNAS (7593229)
Other Database Cross Links
NCBI Entrez Gene:351
HuGE Navigator:351