ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

APP

Full Name:

amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

21q21.2|21q21.3

Physical Location:

26174731-26465002 on NC_000021.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 54226 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

APP

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009986	cell surface	Cellular Component	IDA (7593229)
GO:0031093	platelet alpha granule lumen	Cellular Component	EXP (2110384)
GO:0005905	coated pit	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (10806211)
GO:0005576	extracellular region	Cellular Component	TAS (10806211)
GO:0005576	extracellular region	Cellular Component	EXP (2110384)
GO:0016020	membrane	Cellular Component	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0033130	acetylcholine receptor binding	Molecular Function	IPI (10681545)
GO:0042802	identical protein binding	Molecular Function	IPI (16286452)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	NAS (11279603)
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IDA (10652580)
GO:0007219	Notch signaling pathway	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0006897	endocytosis	Biological Process	IEA
GO:0006878	cellular copper ion homeostasis	Biological Process	TAS (15910549)
GO:0050905	neuromuscular process	Biological Process	NAS (7593229)