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Gene Information
Gene ID:54226
Symbol:App
Full Name:amyloid beta (A4) precursor protein
Organism:Rattus norvegicus (Rat)
Chromosome:11
Genetic Location:11q11
Physical Location:24457854-24693850 on NC_005110.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 351    Symbol (Name): APP (amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease))
Ortholog Status:The human GeneID 351 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:App
Fold Change:-1.13
P Value:0.004
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:App
Fold Change:-1.27
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019288.1NP_062161.1NC_005110.2 range: 24457854..24693850, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030424axonCellular ComponentISS
GO:0043005neuron projectionCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0048471perinuclear region of cytoplasmCellular ComponentISS
GO:0035253ciliary rootletCellular ComponentISS
GO:0009986cell surfaceCellular ComponentISS
GO:0016020membraneCellular ComponentISS
GO:0005794Golgi apparatusCellular ComponentISS
GO:0005794Golgi apparatusCellular ComponentIDA (1331676)
GO:0005737cytoplasmCellular ComponentISS
GO:0031410cytoplasmic vesicleCellular ComponentISS
GO:0031594neuromuscular junctionCellular ComponentISS
GO:0016021integral to membraneCellular ComponentISS
GO:0051233spindle midzoneCellular ComponentISS
GO:0005624membrane fractionCellular ComponentISS
GO:0045177apical part of cellCellular ComponentISS
GO:0033130acetylcholine receptor bindingMolecular FunctionISS
GO:0042802identical protein bindingMolecular FunctionISS
GO:0016504protease activator activityMolecular FunctionIDA (12493564)
GO:0005515protein bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionIEA
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (16118793)
GO:0035235ionotropic glutamate receptor signaling pathwayBiological ProcessISS
GO:0030900forebrain developmentBiological ProcessISS
GO:0051563smooth endoplasmic reticulum calcium ion homeostasisBiological ProcessISS
GO:0031175neurite developmentBiological ProcessISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0040014regulation of multicellular organism growthBiological ProcessISS
GO:0048669collateral sprouting in the absence of injuryBiological ProcessISS
GO:0050803regulation of synapse structure and activityBiological ProcessISS
GO:0051124synaptic growth at neuromuscular junctionBiological ProcessISS
GO:0050885neuromuscular process controlling balanceBiological ProcessISS
GO:0045931positive regulation of mitotic cell cycleBiological ProcessISS
GO:0030198extracellular matrix organization and biogenesisBiological ProcessISS
GO:0007176regulation of epidermal growth factor receptor activityBiological ProcessISS
GO:0006917induction of apoptosisBiological ProcessIDA (12493564)
GO:0006897endocytosisBiological ProcessISS
GO:0006878cellular copper ion homeostasisBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006417regulation of translationBiological ProcessISS
GO:0006378mRNA polyadenylationBiological ProcessISS
GO:0000085G2 phase of mitotic cell cycleBiological ProcessISS
GO:0007409axonogenesisBiological ProcessISS
GO:0007617mating behaviorBiological ProcessISS
GO:0016358dendrite developmentBiological ProcessISS
GO:0016322neuron remodelingBiological ProcessISS
GO:0016199axon midline choice point recognitionBiological ProcessISS
GO:0008088axon cargo transportBiological ProcessISS
GO:0008542visual learningBiological ProcessISS
GO:0008344adult locomotory behaviorBiological ProcessISS
GO:0008088axon cargo transportBiological ProcessISS
GO:0007626locomotory behaviorBiological ProcessISS
GO:0001967suckling behaviorBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:54226
RGD:2139
Ensembl:ENSRNOG00000006997
dbSNP:App