ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

gus

Alias:

A11|CG2944|CG2946|dmSSB4|i25

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

41D3-41D3

Physical Location:

1004714-1015816 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 80176 Symbol (Name): SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1)

Ortholog Status:

The human GeneID 80176 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0007314	oocyte anterior/posterior axis determination	Biological Process	IMP (12479811)
GO:0046843	dorsal appendage formation	Biological Process	IMP (12479811)