ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

jing

Alias:

1.28|CG9397|CG9403|CT9093|Dmel_CG9403|l(2)01094|l(2)22F3

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

42B3-42B3

Physical Location:

2389763-2506900 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (11152631)
GO:0005634	nucleus	Cellular Component	ISS (11152631)
GO:0005634	nucleus	Cellular Component	NAS
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016564	transcription repressor activity	Molecular Function	IMP (16510782)
GO:0003700	transcription factor activity	Molecular Function	NAS
GO:0008347	glial cell migration	Biological Process	IMP (16648585)
GO:0007479	leg disc proximal/distal pattern formation	Biological Process	IMP (16510782)
GO:0007474	imaginal disc-derived wing vein specification	Biological Process	IMP (16510782)
GO:0007424	open tracheal system development	Biological Process	IMP (12015288)
GO:0007417	central nervous system development	Biological Process	IMP (12015288\|12111212)
GO:0007411	axon guidance	Biological Process	IMP (16648585)
GO:0007382	specification of segmental identity, maxillary segment	Biological Process	IGI (8104141)
GO:0007382	specification of segmental identity, maxillary segment	Biological Process	IEP (8104141)
GO:0007298	border follicle cell migration	Biological Process	IMP (11152631)
GO:0045449	regulation of transcription	Biological Process	NAS