ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

pnut

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

44C2-44C2

Physical Location:

4124773-4127834 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		pnut
P Value:		3.87E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045172	germline ring canal	Cellular Component	NAS (11131529)
GO:0045171	intercellular bridge	Cellular Component	NAS
GO:0005940	septin ring	Cellular Component	ISS (10908588)
GO:0016324	apical plasma membrane	Cellular Component	NAS
GO:0005525	GTP binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IDA (11076973)
GO:0008017	microtubule binding	Molecular Function	IDA (11076973)
GO:0042051	compound eye photoreceptor development	Biological Process	NAS
GO:0007349	cellularization	Biological Process	TAS (11700298\|12386932)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IGI (15029247)
GO:0006904	vesicle docking during exocytosis	Biological Process	TAS (11076973)
GO:0006903	vesicle targeting	Biological Process	TAS (11076973)
GO:0000915	cytokinesis, contractile ring formation	Biological Process	NAS (11700298)
GO:0000910	cytokinesis	Biological Process	TAS (11076973)
GO:0000910	cytokinesis	Biological Process	NAS
GO:0000910	cytokinesis	Biological Process	ISS (10908588)
GO:0000910	cytokinesis	Biological Process	IMP (15380073)