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Gene Information
Gene ID:3586
Symbol:IL10
Full Name:interleukin 10
Alias:CSIF|IL-10|IL10A|MGC126450|MGC126451|TGIF
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1q31-q32
Physical Location:205007570-205012461 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 16153 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:IL10
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
IL105Alcohol-Induced Disorders
IL103Alcoholism
IL105Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000572.2NP_000563.1NC_000001.9 range: 205007570..205012461, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentNAS (1847510)
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005125cytokine activityMolecular FunctionIEA
GO:0005141interleukin-10 receptor bindingMolecular FunctionNAS (1847510)
GO:0005515protein bindingMolecular FunctionIPI (11485736)
GO:0042100B cell proliferationBiological ProcessNAS (8228801)
GO:0042092T-helper 2 type immune responseBiological ProcessTAS (11244051)
GO:0002237response to molecule of bacterial originBiological ProcessIDA (17449476)
GO:0032800receptor biosynthetic processBiological ProcessIDA (10443688)
GO:0042130negative regulation of T cell proliferationBiological ProcessNAS (8499633)
GO:0045191regulation of isotype switchingBiological ProcessNAS (8228801)
GO:0045347negative regulation of MHC class II biosynthetic processBiological ProcessTAS (11244051)
GO:0045355negative regulation of interferon-alpha biosynthetic processBiological ProcessNAS (9637497)
GO:0050715positive regulation of cytokine secretionBiological ProcessIDA (10443688)
GO:0032715negative regulation of interleukin-6 productionBiological ProcessIDA (10443688)
GO:0030595leukocyte chemotaxisBiological ProcessTAS (9405662)
GO:0030183B cell differentiationBiological ProcessNAS (8228801)
GO:0002740negative regulation of cytokine secretion during immune responseBiological ProcessIDA (10443688)
GO:0006916anti-apoptosisBiological ProcessNAS (8312229)
GO:0006954inflammatory responseBiological ProcessNAS (9463379)
GO:0006955immune responseBiological ProcessIEA
GO:0007253cytoplasmic sequestering of NF-kappaBBiological ProcessNAS (10975994)
GO:0007267cell-cell signalingBiological ProcessIC (1847510)
GO:0010468regulation of gene expressionBiological ProcessIDA (9184696)
GO:0030097hemopoiesisBiological ProcessTAS (11244051)
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (10443688)
Other Database Cross Links
NCBI Entrez Gene:3586
HGNC:5962
Ensembl:ENSG00000136634
MIM:124092
HPRD:00495
HuGE Navigator:3586
dbSNP:IL10
GeneCard:IL10
AceView:IL10