ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ggamma1

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

44F3-44F5

Physical Location:

4788907-4792295 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55970 Symbol (Name): GNG12 (guanine nucleotide binding protein (G protein), gamma 12)

Ortholog Status:

The human GeneID 55970 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	IEA
GO:0005834	heterotrimeric G-protein complex	Cellular Component	NAS (10471706)
GO:0003924	GTPase activity	Molecular Function	NAS (10471706)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0045176	apical protein localization	Biological Process	TAS (15324689)
GO:0035050	embryonic heart tube development	Biological Process	IMP (16857902)
GO:0008360	regulation of cell shape	Biological Process	IMP (14527345)
GO:0007637	proboscis extension reflex	Biological Process	IMP (16121192)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	NAS (10471706)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IMP (14527345)
GO:0007015	actin filament organization	Biological Process	IMP (14527345)
GO:0055059	asymmetric neuroblast division	Biological Process	IMP (14981094)