ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdk

Alias:

BcDNA:LD09837|CG8808|DmPDK

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

45D5-45D7

Physical Location:

5313946-5321929 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5165 Symbol (Name): PDK3 (pyruvate dehydrogenase kinase, isozyme 3)

Ortholog Status:

The human GeneID 5165 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005759	mitochondrial matrix	Cellular Component	ISS
GO:0005759	mitochondrial matrix	Cellular Component	NAS
GO:0000155	two-component sensor activity	Molecular Function	IEA
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Molecular Function	ISS
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	Molecular Function	NAS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0006090	pyruvate metabolic process	Biological Process	ISS
GO:0007165	signal transduction	Biological Process	IEA
GO:0018106	peptidyl-histidine phosphorylation	Biological Process	IEA