ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

360406

Symbol:

Ptprf

Full Name:

protein tyrosine phosphatase, receptor type, F

Alias:

LARFN5C

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q36

Physical Location:

138671714-138739001 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5792 Symbol (Name): PTPRF (protein tyrosine phosphatase, receptor type, F)

Ortholog Status:

The human GeneID 5792 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ptprf
Fold Change:		1.17
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019249.1	NP_062122.1	NC_005104.2 range: 138671714..138739001, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0060076	excitatory synapse	Cellular Component	IDA (15750591)
GO:0043025	cell soma	Cellular Component	IDA (9748473)
GO:0043005	neuron projection	Cellular Component	IDA (9748473)
GO:0030426	growth cone	Cellular Component	IDA (9604206)
GO:0005886	plasma membrane	Cellular Component	IDA (10692429)
GO:0005792	microsome	Cellular Component	IDA (10692429)
GO:0005768	endosome	Cellular Component	IDA (16269466)
GO:0005624	membrane fraction	Cellular Component	IDA (12365558)
GO:0042301	phosphate binding	Molecular Function	IDA (1918076)
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IDA (8068021)
GO:0030971	receptor tyrosine kinase binding	Molecular Function	IPI (16415345)
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0043525	positive regulation of neuron apoptosis	Biological Process	IMP (10699984)
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IMP (8557682)
GO:0050775	positive regulation of dendrite morphogenesis	Biological Process	IMP (15750591)
GO:0043065	positive regulation of apoptosis	Biological Process	IDA (9501065)
GO:0050803	regulation of synapse structure and activity	Biological Process	IMP (15750591)
GO:0051387	negative regulation of nerve growth factor receptor signaling pathway	Biological Process	IMP (10699984)
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	IMP (8557682)
GO:0031345	negative regulation of cell projection organization and biogenesis	Biological Process	IMP (10699984)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (16415345)
GO:0007399	nervous system development	Biological Process	IDA (12716943)
GO:0007156	homophilic cell adhesion	Biological Process	IDA (12716943)
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (8068021)
GO:0001960	negative regulation of cytokine and chemokine mediated signaling pathway	Biological Process	IMP (16415345)