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Gene Information
Gene ID:36080
Symbol:Syb
Alias:21.15|CG12210|J|VAMP|c-Syb|l(2)46CFq|l(2)46El|unnamed
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:46F8-46F8
Physical Location:6136981-6139913 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Syb
P Value:4.61E-02
Note:Acute up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078956.2NP_523680.1NT_033778.3 range: 6136981..6139913, complement
NM_165756.1NP_724906.1NT_033778.3 range: 6136981..6139913, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentNAS (10218158|10471706)
GO:0008021synaptic vesicleCellular ComponentNAS (10798391)
GO:0008021synaptic vesicleCellular ComponentISS (10908590)
GO:0005484SNAP receptor activityMolecular FunctionISS (10908590)
GO:0005484SNAP receptor activityMolecular FunctionNAS (10218158|10471706)
GO:0007269neurotransmitter secretionBiological ProcessNAS (10798391)
GO:0016081synaptic vesicle docking during exocytosisBiological ProcessISS (10908590)
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessISS (10908590)
GO:0016192vesicle-mediated transportBiological ProcessNAS (10798391)
GO:0035149lumen formation, open tracheal systemBiological ProcessTAS (14570584)
GO:0048489synaptic vesicle transportBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:36080
FLYBASE:FBgn0003660