ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Enah

Full Name:

enabled homolog (Drosophila)

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

13q26

Physical Location:

97919689-98025152 on NC_005112.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55740 Symbol (Name): ENAH (enabled homolog (Drosophila))

Ortholog Status:

The human GeneID 55740 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Enah
Fold Change:		-1.13
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001012150.1	NP_001012150.1	NC_005112.2 range: 97919689..98025152, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001725	stress fiber	Cellular Component	ISS
GO:0030175	filopodium	Cellular Component	ISS
GO:0005925	focal adhesion	Cellular Component	ISS
GO:0030027	lamellipodium	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0005522	profilin binding	Molecular Function	ISS
GO:0017124	SH3 domain binding	Molecular Function	ISS
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	ISS
GO:0008154	actin polymerization and/or depolymerization	Biological Process	ISS
GO:0007411	axon guidance	Biological Process	ISS
GO:0007015	actin filament organization	Biological Process	ISS
GO:0006928	cell motility	Biological Process	ISS
GO:0001843	neural tube closure	Biological Process	ISS
GO:0046907	intracellular transport	Biological Process	IEA