Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:360891
Full Name:enabled homolog (Drosophila)
Organism:Rattus norvegicus (Rat)
Genetic Location:13q26
Physical Location:97919689-98025152 on NC_005112.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 55740    Symbol (Name): ENAH (enabled homolog (Drosophila))
Ortholog Status:The human GeneID 55740 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Enah
Fold Change:-1.13
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012150.1NP_001012150.1NC_005112.2 range: 97919689..98025152, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001725stress fiberCellular ComponentISS
GO:0030175filopodiumCellular ComponentISS
GO:0005925focal adhesionCellular ComponentISS
GO:0030027lamellipodiumCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005522profilin bindingMolecular FunctionISS
GO:0017124SH3 domain bindingMolecular FunctionISS
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessISS
GO:0008154actin polymerization and/or depolymerizationBiological ProcessISS
GO:0007411axon guidanceBiological ProcessISS
GO:0007015actin filament organizationBiological ProcessISS
GO:0006928cell motilityBiological ProcessISS
GO:0001843neural tube closureBiological ProcessISS
GO:0046907intracellular transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:360891