ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Polr3a

Full Name:

polymerase (RNA) III (DNA directed) polypeptide A

Alias:

RGD1305574

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16p16

Physical Location:

3862-42285 on NC_005115.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 11128 Symbol (Name): POLR3A (polymerase (RNA) III (DNA directed) polypeptide A, 155kDa)

Ortholog Status:

The human GeneID 11128 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.41904
Fold Change:		1.23
P Value:		0.00731
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_341388.3	XP_341389.3	NC_005115.2 range: 3862..42285, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003899	DNA-directed RNA polymerase activity	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA