ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

361532

Symbol:

Sirt2

Full Name:

sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

Alias:

MGC105900

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q21

Physical Location:

83873577-83896120 on NC_005100.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 22933 Symbol (Name): SIRT2 (sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae))

Ortholog Status:

The human GeneID 22933 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sirt2
Fold Change:		1.16
P Value:		0.002
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001008368.1	NP_001008369.1	NC_005100.2 range: 83873577..83896120

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005874	microtubule	Cellular Component	ISS
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005677	chromatin silencing complex	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0008270	zinc ion binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0035035	histone acetyltransferase binding	Molecular Function	ISS
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	IEA
GO:0042826	histone deacetylase binding	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0042903	tubulin deacetylase activity	Molecular Function	ISS
GO:0043130	ubiquitin binding	Molecular Function	ISS
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	ISS
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0045843	negative regulation of striated muscle development	Biological Process	ISS
GO:0016481	negative regulation of transcription	Biological Process	ISS
GO:0008150	biological_process	Biological Process	ND
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006476	protein amino acid deacetylation	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006342	chromatin silencing	Biological Process	IEA
GO:0051301	cell division	Biological Process	IEA