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Gene Information
Gene ID:362715
Symbol:Dtnb
Full Name:dystrobrevin, beta
Organism:Rattus norvegicus (Rat)
Chromosome:6
Genetic Location:6q14
Physical Location:26542147-26742198 on NC_005105.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1838    Symbol (Name): DTNB (dystrobrevin, beta)
Ortholog Status:The human GeneID 1838 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dtnb
Fold Change:1.14
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012191.1NP_001012191.1NC_005105.2 range: 26542147..26742198
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0045202synapseCellular ComponentISS
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI
GO:0005515protein bindingMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:362715
RGD:1309579
Ensembl:ENSRNOG00000011914
dbSNP:Dtnb