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Gene Information
Gene ID:362849
Symbol:March2
Full Name:membrane-associated ring finger (C3HC4) 2
Alias:MARCH-II|RGD1306395
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q12
Physical Location:16193113-16219080 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:MARCH2
Fold Change:1.15
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001012196.2NP_001012196.1NC_005106.2 range: 16193113..16219080, complement
NM_001034108.1NP_001029280.1NC_005106.2 range: 16193113..16219080, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005765lysosomal membraneCellular ComponentIEA
GO:0005768endosomeCellular ComponentIEA
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0010008endosome membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0006897endocytosisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:362849
RGD:1306395
Ensembl:ENSRNOG00000007769
dbSNP:March2