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Gene Information
Gene ID:36319
Symbol:CG8858
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:48E8-48E8
Physical Location:8079871-8086342 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG8858
P Value:2.18E-02
Note:Acute down-regulation, have human orthologs
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_136902.2NP_610746.1NT_033778.3 range: 8079871..8086342, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000502proteasome complexCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005515protein bindingMolecular FunctionISS
GO:0030163protein catabolic processBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:36319
FLYBASE:FBgn0033698