Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:363425
Full Name:caveolin 2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q21
Physical Location:42932126-42939502 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 858    Symbol (Name): CAV2 (caveolin 2)
Ortholog Status:The human GeneID 858 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cav2
Fold Change:1.17
P Value:0.003
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Cav2
Fold Change:1.21
P Value:0.001
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Gene Information
Original ID1:Cav2
Fold Change:1.16
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_131914.2NP_571989.2NC_005103.2 range: 42932126..42939502
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0005578proteinaceous extracellular matrixCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentISS
GO:0005887integral to plasma membraneCellular ComponentISS
GO:0005901caveolaCellular ComponentISS
GO:0048471perinuclear region of cytoplasmCellular ComponentISS
GO:0030133transport vesicleCellular ComponentISS
GO:0008290F-actin capping protein complexCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0000149SNARE bindingMolecular FunctionIDA (11883949)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0019905syntaxin bindingMolecular FunctionIDA (11883949)
GO:0042803protein homodimerization activityMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionIEA
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIEA
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0048741skeletal muscle fiber developmentBiological ProcessISS
GO:0051016barbed-end actin filament cappingBiological ProcessIEA
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessIEA
GO:0048278vesicle dockingBiological ProcessISS
GO:0016050vesicle organization and biogenesisBiological ProcessISS
GO:0008285negative regulation of cell proliferationBiological ProcessISS
GO:0001937negative regulation of endothelial cell proliferationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006906vesicle fusionBiological ProcessISS
GO:0007005mitochondrion organization and biogenesisBiological ProcessISS
GO:0007029endoplasmic reticulum organization and biogenesisBiological ProcessISS
GO:0007223Wnt receptor signaling pathway, calcium modulating pathwayBiological ProcessIEA
GO:0007268synaptic transmissionBiological ProcessIDA (11883949)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0051259protein oligomerizationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:363425