ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

363425

Symbol:

Cav2

Full Name:

caveolin 2

Alias:

MGC72322

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q21

Physical Location:

42932126-42939502 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 858 Symbol (Name): CAV2 (caveolin 2)

Ortholog Status:

The human GeneID 858 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cav2
Fold Change:		1.17
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Cav2
Fold Change:		1.21
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Cav2
Fold Change:		1.16
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_131914.2	NP_571989.2	NC_005103.2 range: 42932126..42939502

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005887	integral to plasma membrane	Cellular Component	ISS
GO:0005901	caveola	Cellular Component	ISS
GO:0048471	perinuclear region of cytoplasm	Cellular Component	ISS
GO:0030133	transport vesicle	Cellular Component	ISS
GO:0008290	F-actin capping protein complex	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0000149	SNARE binding	Molecular Function	IDA (11883949)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019905	syntaxin binding	Molecular Function	IDA (11883949)
GO:0042803	protein homodimerization activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0048741	skeletal muscle fiber development	Biological Process	ISS
GO:0051016	barbed-end actin filament capping	Biological Process	IEA
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IEA
GO:0048278	vesicle docking	Biological Process	ISS
GO:0016050	vesicle organization and biogenesis	Biological Process	ISS
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS
GO:0001937	negative regulation of endothelial cell proliferation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006906	vesicle fusion	Biological Process	ISS
GO:0007005	mitochondrion organization and biogenesis	Biological Process	ISS
GO:0007029	endoplasmic reticulum organization and biogenesis	Biological Process	ISS
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	IDA (11883949)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0051259	protein oligomerization	Biological Process	ISS