ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

EIF3E

Full Name:

eukaryotic translation initiation factor 3, subunit E

Alias:

EIF3-P48|EIF3S6|INT6|eIF3-p46

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q22-q23

Physical Location:

109283147-109330134 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 16341 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.405590
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001568.2	NP_001559.1	NC_000008.9 range: 109283147..109330134, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (12588972)
GO:0005852	eukaryotic translation initiation factor 3 complex	Cellular Component	TAS (9295280)
GO:0003743	translation initiation factor activity	Molecular Function	TAS (9295280)
GO:0005515	protein binding	Molecular Function	IPI (14667819\|17220478\|17324924\|17353931)
GO:0006412	translation	Biological Process	IEA
GO:0006446	regulation of translational initiation	Biological Process	TAS (9295280)