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Gene Information
Gene ID:37230
Symbol:hts
Alias:1B1|ADD-87|Add|Add-hts|Adducin|CG9325|EST D|HTS-RC|HtsF|HtsRC|Ovhts|anon-EST:Posey9|l(2)00634|l(2)01103|l(2)k06121|l(2)k14523
Organism:Drosophila melanogaster (Fly)
Chromosome:2R
Genetic Location:56D3-56D5
Physical Location:15284839-15312453 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 118    Symbol (Name): ADD1 (adducin 1 (alpha))
Ortholog Status:The human GeneID 118 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:hts
P Value:4.65E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057529.2NP_476877.1NT_033778.3 range: 15284839..15312453, complement
NM_166347.1NP_725886.1NT_033778.3 range: 15284839..15312453, complement
NM_166348.1NP_725887.1NT_033778.3 range: 15284839..15312453, complement
NM_166349.1NP_725888.1NT_033778.3 range: 15284839..15312453, complement
NM_166350.1NP_725889.1NT_033778.3 range: 15284839..15312453, complement
NM_166351.1NP_725890.1NT_033778.3 range: 15284839..15312453, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045169fusomeCellular ComponentIDA (7555720|7600970|15993631|17215303)
GO:0045169fusomeCellular ComponentNAS (11131529)
GO:0045170spectrosomeCellular ComponentIDA (7555720)
GO:0035183germline ring canal inner rimCellular ComponentTAS (9093858|10556087)
GO:0045170spectrosomeCellular ComponentTAS (11131529)
GO:0045172germline ring canalCellular ComponentIDA (10471713)
GO:0045172germline ring canalCellular ComponentNAS
GO:0045172germline ring canalCellular ComponentTAS (9012516)
GO:0005886plasma membraneCellular ComponentIDA (17215303)
GO:0005811lipid particleCellular ComponentIDA
GO:0045169fusomeCellular ComponentTAS (9012516|10370240)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionISS
GO:0045478fusome organization and biogenesisBiological ProcessTAS (7555720|10370240|11131529)
GO:0048134germ-line cyst formationBiological ProcessTAS (10370240)
GO:0048135female germ-line cyst formationBiological ProcessTAS (9012516)
GO:0000212meiotic spindle organization and biogenesisBiological ProcessIMP (15993631)
GO:0007282cystoblast divisionBiological ProcessIMP (15292454)
GO:0007294germarium-derived oocyte fate determinationBiological ProcessTAS (9012516|11131529)
GO:0008302ring canal formation, actin assemblyBiological ProcessIMP (1340461)
GO:0008302ring canal formation, actin assemblyBiological ProcessNAS
GO:0008302ring canal formation, actin assemblyBiological ProcessTAS (9012516)
GO:0030721spectrosome organization and biogenesisBiological ProcessTAS (11131529)
GO:0030723ovarian fusome organization and biogenesisBiological ProcessIMP (15292454)
GO:0030724testicular fusome organization and biogenesisBiological ProcessIMP (15993631)
GO:0051297centrosome organization and biogenesisBiological ProcessIMP (15993631)
Other Database Cross Links
NCBI Entrez Gene:37230
FLYBASE:FBgn0004873