ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG33671

Alias:

CG16804|CG33009|CG8810

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

49B10-49B10

Physical Location:

8521667-8523665 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4598 Symbol (Name): MVK (mevalonate kinase)

Ortholog Status:

The human GeneID 4598 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG33671
P Value:		1.35E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001032241.1	NP_001027412.1	NT_033778.3 range: 8521667..8523665, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004496	mevalonate kinase activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008299	isoprenoid biosynthetic process	Biological Process	IEA
GO:0016310	phosphorylation	Biological Process	ISS