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Gene Information
Gene ID:37959
Organism:Drosophila melanogaster (Fly)
Genetic Location:60E1-60E1
Physical Location:20650686-20654272 on NT_033778.3
Gene Type:protein-coding
Human Ortholog:GeneID: 140825    Symbol (Name): NEURL2 (neuralized homolog 2 (Drosophila))
Ortholog Status:The human GeneID 140825 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG3894
P Value:1.55E-02
Note:Slow up-regulation, have human orthologs
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_138119.5NP_611963.4NT_033778.3 range: 20650686..20654272
NM_166685.1NP_726480.1NT_033778.3 range: 20650686..20654272
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0007242intracellular signaling cascadeBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:37959