ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dll

Alias:

2.7|Art|Ba|BcDNA:LP01770|CG3629|E(Arp)|En(Arp)|l(2)01092|l(2)387

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

60E2-60E2

Physical Location:

20702352-20722685 on NT_033778.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1746 Symbol (Name): DLX2 (distal-less homeobox 2)

Ortholog Status:

The human GeneID 1746 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dll
P Value:		3.20E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0010092	specification of organ identity	Biological Process	IMP (11934862)
GO:0035109	imaginal disc-derived limb morphogenesis	Biological Process	NAS
GO:0035110	leg morphogenesis	Biological Process	TAS (18088998)
GO:0035215	genital disc development	Biological Process	TAS (11494318)
GO:0009954	proximal/distal pattern formation	Biological Process	TAS (11934862)
GO:0007487	analia development	Biological Process	TAS (11494318)
GO:0007485	imaginal disc-derived male genitalia development	Biological Process	NAS (11494318)
GO:0007479	leg disc proximal/distal pattern formation	Biological Process	TAS (10497093\|10625531\|11494318\|12181552)
GO:0007469	antennal development	Biological Process	TAS (11494318\|11875444)
GO:0007449	proximal/distal pattern formation, imaginal disc	Biological Process	TAS (11494318)
GO:0007449	proximal/distal pattern formation, imaginal disc	Biological Process	NAS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0048728	proboscis development	Biological Process	IMP (17027238)