ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

gol

Alias:

CG2679|anon-G1|g1|meso

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

60F3-60F3

Physical Location:

20960142-20971842 on NT_033778.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57484 Symbol (Name): RNF150 (ring finger protein 150)

Ortholog Status:

The human GeneID 57484 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		gol
P Value:		3.25E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS (8462875)
GO:0005515	protein binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0030528	transcription regulator activity	Molecular Function	IEP (8462875)
GO:0001707	mesoderm formation	Biological Process	IEP (8462875)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS
GO:0007498	mesoderm development	Biological Process	NAS
GO:0045449	regulation of transcription	Biological Process	IEP (8462875)