ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

n-syb

Alias:

CG17248|Dn-syb|Nsyb|SYB|Syb62A

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

62A9-62A9

Physical Location:

1631680-1637766 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6844 Symbol (Name): VAMP2 (vesicle-associated membrane protein 2 (synaptobrevin 2))

Ortholog Status:

The human GeneID 6844 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		n-syb
P Value:		4.27E-02
Note:		Slow up-regulation, have mouse orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008021	synaptic vesicle	Cellular Component	NAS (10798391)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	NAS (10218158)
GO:0008021	synaptic vesicle	Cellular Component	ISS (10908590)
GO:0005484	SNAP receptor activity	Molecular Function	ISS (10908590)
GO:0005484	SNAP receptor activity	Molecular Function	NAS (10218158)
GO:0007269	neurotransmitter secretion	Biological Process	NAS (10798391)
GO:0016081	synaptic vesicle docking during exocytosis	Biological Process	ISS (10908590)
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	ISS (10908590)
GO:0016192	vesicle-mediated transport	Biological Process	NAS (10798391)