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Gene Information
Gene ID:38565
Symbol:Rpd3
Alias:CG7471|DRpd3|DmHDAC1|E(var)3-64BC|HDAC|HDAC-1|HDAC1|Rpd3/HDAC|Su(var)326|Su(var)328|dHDAC-1|dHDAC1|dmHDA401|l(3)04556|l(3)64Cc|rpd[3]
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:64B12-64B12
Physical Location:4626716-4629470 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:GeneID: 3066    Symbol (Name): HDAC2 (histone deacetylase 2)
Ortholog Status:The human GeneID 3066 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rpd3
P Value:4.38E-04
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_139661.2NP_647918.2NT_037436.3 range: 4626716..4629470
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000785chromatinCellular ComponentIDA (11080159)
GO:0035098ESC/E(Z) complexCellular ComponentTAS (14698615)
GO:0005634nucleusCellular ComponentNAS
GO:0005634nucleusCellular ComponentIDA (11080159|11124122)
GO:0035098ESC/E(Z) complexCellular ComponentIDA (12408863)
GO:0031523Myb complexCellular ComponentIDA (15545624)
GO:0016581NuRD complexCellular ComponentNAS (11080159)
GO:0016581NuRD complexCellular ComponentIPI (11743021)
GO:0016580Sin3 complexCellular ComponentNAS (11080159)
GO:0046974histone lysine N-methyltransferase activity (H3-K9 specific)Molecular FunctionIC (12408863)
GO:0046976histone lysine N-methyltransferase activity (H3-K27 specific)Molecular FunctionIC (12408863)
GO:0005515protein bindingMolecular FunctionIPI (12697833|15545624)
GO:0004407histone deacetylase activityMolecular FunctionNAS (11691830)
GO:0004407histone deacetylase activityMolecular FunctionISS (8955276)
GO:0004407histone deacetylase activityMolecular FunctionIDA (11278256|11281647|16137856)
GO:0003714transcription corepressor activityMolecular FunctionNAS (11691830)
GO:0048477oogenesisBiological ProcessTAS (11691830)
GO:0016575histone deacetylationBiological ProcessNAS (11691830)
GO:0016575histone deacetylationBiological ProcessIEA
GO:0016571histone methylationBiological ProcessIDA (12408863)
GO:0006342chromatin silencingBiological ProcessIGI (11493709)
GO:0006342chromatin silencingBiological ProcessIPI (11124122|11493709)
GO:0007350blastoderm segmentationBiological ProcessIMP (10359792)
GO:0007517muscle developmentBiological ProcessIMP (16547170)
GO:0008340determination of adult life spanBiological ProcessIMP (12459580)
GO:0008340determination of adult life spanBiological ProcessTAS (14616064)
GO:0016458gene silencingBiological ProcessIMP (11124122)
GO:0016481negative regulation of transcriptionBiological ProcessIEP (11080159)
GO:0016481negative regulation of transcriptionBiological ProcessNAS (11691830)
GO:0048813dendrite morphogenesisBiological ProcessIMP (16547170)
Other Database Cross Links
NCBI Entrez Gene:38565
FLYBASE:FBgn0015805