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Gene Information
Gene ID:38586
Organism:Drosophila melanogaster (Fly)
Genetic Location:64C1-64C2
Physical Location:4861459-4895290 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:GeneID: 55567    Symbol (Name): DNAH3 (dynein, axonemal, heavy chain 3)
Ortholog Status:The human GeneID 55567 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG17150
P Value:1.35E-02
Note:Slow up-regulation, have human orthologs
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_139680.1NP_647937.1NT_037436.3 range: 4861459..4895290
NM_168106.1NP_729040.1NT_037436.3 range: 4861459..4895290
NM_168107.1NP_729041.1NT_037436.3 range: 4861459..4895290
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030286dynein complexCellular ComponentISS (10908588)
GO:0030286dynein complexCellular ComponentIEA
GO:0005875microtubule associated complexCellular ComponentISS
GO:0003774motor activityMolecular FunctionISS
GO:0016887ATPase activityMolecular FunctionIEA
GO:0042623ATPase activity, coupledMolecular FunctionISS (10908588)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0003777microtubule motor activityMolecular FunctionIEA
GO:0007018microtubule-based movementBiological ProcessIEA
GO:0007018microtubule-based movementBiological ProcessISS (10908588)
Other Database Cross Links
NCBI Entrez Gene:38586