ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG17150

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

64C1-64C2

Physical Location:

4861459-4895290 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55567 Symbol (Name): DNAH3 (dynein, axonemal, heavy chain 3)

Ortholog Status:

The human GeneID 55567 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG17150
P Value:		1.35E-02
Note:		Slow up-regulation, have human orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030286	dynein complex	Cellular Component	ISS (10908588)
GO:0030286	dynein complex	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	ISS
GO:0003774	motor activity	Molecular Function	ISS
GO:0016887	ATPase activity	Molecular Function	IEA
GO:0042623	ATPase activity, coupled	Molecular Function	ISS (10908588)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003777	microtubule motor activity	Molecular Function	IEA
GO:0007018	microtubule-based movement	Biological Process	IEA
GO:0007018	microtubule-based movement	Biological Process	ISS (10908588)