ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ect4

Alias:

CG13680|CG34373|CG7905|CG7915|Dmel_CG13680|Dmel_CG7915|anon-WO0118547.272

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

66B5-66B5

Physical Location:

8067546-8101937 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ect4
P Value:		4.52E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031224	intrinsic to membrane	Cellular Component	IEA
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0045087	innate immune response	Biological Process	IEA