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Gene Information
Gene ID:38898
Symbol:Arp66B
Alias:ARP3|AcTr66B|CG7558|anon-WO0172774.138
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:66B6-66B6
Physical Location:8106587-8108999 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10096    Symbol (Name): ACTR3 (ARP3 actin-related protein 3 homolog (yeast))
Ortholog Status:The human GeneID 10096 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Arp66B
P Value:2.64E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079244.2NP_523968.1NT_037436.3 range: 8106587..8108999, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005884actin filamentCellular ComponentISS (8064864)
GO:0005885Arp2/3 protein complexCellular ComponentISS (10908588)
GO:0005885Arp2/3 protein complexCellular ComponentNAS (15196561)
GO:0015629actin cytoskeletonCellular ComponentNAS
GO:0003779actin bindingMolecular FunctionISS
GO:0005200structural constituent of cytoskeletonMolecular FunctionISS (10908588)
GO:0030037actin filament reorganization during cell cycleBiological ProcessIPI (12007413)
GO:0008335ovarian ring canal stabilizationBiological ProcessIMP (11854308)
GO:0008064regulation of actin polymerization and/or depolymerizationBiological ProcessNAS
GO:0007413axonal fasciculationBiological ProcessIMP (11854309)
GO:0007303cytoplasmic transport, nurse cell to oocyteBiological ProcessIMP (11854308)
GO:0007010cytoskeleton organization and biogenesisBiological ProcessISS (10908588)
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
GO:0030589pseudocleavage during syncytial blastoderm formationBiological ProcessIPI (12007413)
Other Database Cross Links
NCBI Entrez Gene:38898
FLYBASE:FBgn0011744