ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Arp66B

Alias:

ARP3|AcTr66B|CG7558|anon-WO0172774.138

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

66B6-66B6

Physical Location:

8106587-8108999 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10096 Symbol (Name): ACTR3 (ARP3 actin-related protein 3 homolog (yeast))

Ortholog Status:

The human GeneID 10096 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Arp66B
P Value:		2.64E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079244.2	NP_523968.1	NT_037436.3 range: 8106587..8108999, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005884	actin filament	Cellular Component	ISS (8064864)
GO:0005885	Arp2/3 protein complex	Cellular Component	ISS (10908588)
GO:0005885	Arp2/3 protein complex	Cellular Component	NAS (15196561)
GO:0015629	actin cytoskeleton	Cellular Component	NAS
GO:0003779	actin binding	Molecular Function	ISS
GO:0005200	structural constituent of cytoskeleton	Molecular Function	ISS (10908588)
GO:0030037	actin filament reorganization during cell cycle	Biological Process	IPI (12007413)
GO:0008335	ovarian ring canal stabilization	Biological Process	IMP (11854308)
GO:0008064	regulation of actin polymerization and/or depolymerization	Biological Process	NAS
GO:0007413	axonal fasciculation	Biological Process	IMP (11854309)
GO:0007303	cytoplasmic transport, nurse cell to oocyte	Biological Process	IMP (11854308)
GO:0007010	cytoskeleton organization and biogenesis	Biological Process	ISS (10908588)
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (16336044)
GO:0030589	pseudocleavage during syncytial blastoderm formation	Biological Process	IPI (12007413)