ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

rhea

Alias:

CG6831|CT21159|Talin|Tln

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

66D6-66D7

Physical Location:

8554356-8567499 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 83660 Symbol (Name): TLN2 (talin 2)

Ortholog Status:

The human GeneID 83660 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		rhea
P Value:		1.40E-03
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_139981.2	NP_648238.1	NT_037436.3 range: 8554356..8567499

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001726	ruffle	Cellular Component	IEA
GO:0005925	focal adhesion	Cellular Component	ISS (10908592)
GO:0005925	focal adhesion	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005200	structural constituent of cytoskeleton	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	ISS (10908588)
GO:0003779	actin binding	Molecular Function	IEA
GO:0032582	negative regulation of gene-specific transcription	Biological Process	IMP (15852002)
GO:0016203	muscle attachment	Biological Process	IMP (9136017)
GO:0008360	regulation of cell shape	Biological Process	IMP (14527345)
GO:0007475	apposition of dorsal and ventral imaginal disc-derived wing surfaces	Biological Process	IMP (9136017)
GO:0007155	cell adhesion	Biological Process	TAS (12361595)
GO:0007155	cell adhesion	Biological Process	IMP (14527345)
GO:0007016	cytoskeletal anchoring	Biological Process	ISS (10908592)
GO:0007016	cytoskeletal anchoring	Biological Process	IEA
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (16336044)
GO:0035160	maintenance of epithelial integrity, open tracheal system	Biological Process	IMP (16720877)