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Gene Information
Gene ID:38978
Organism:Drosophila melanogaster (Fly)
Genetic Location:66D6-66D7
Physical Location:8554356-8567499 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:GeneID: 83660    Symbol (Name): TLN2 (talin 2)
Ortholog Status:The human GeneID 83660 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:rhea
P Value:1.40E-03
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_139981.2NP_648238.1NT_037436.3 range: 8554356..8567499
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001726ruffleCellular ComponentIEA
GO:0005925focal adhesionCellular ComponentISS (10908592)
GO:0005925focal adhesionCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005200structural constituent of cytoskeletonMolecular FunctionIEA
GO:0003779actin bindingMolecular FunctionISS (10908588)
GO:0003779actin bindingMolecular FunctionIEA
GO:0032582negative regulation of gene-specific transcriptionBiological ProcessIMP (15852002)
GO:0016203muscle attachmentBiological ProcessIMP (9136017)
GO:0008360regulation of cell shapeBiological ProcessIMP (14527345)
GO:0007475apposition of dorsal and ventral imaginal disc-derived wing surfacesBiological ProcessIMP (9136017)
GO:0007155cell adhesionBiological ProcessTAS (12361595)
GO:0007155cell adhesionBiological ProcessIMP (14527345)
GO:0007016cytoskeletal anchoringBiological ProcessISS (10908592)
GO:0007016cytoskeletal anchoringBiological ProcessIEA
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
GO:0035160maintenance of epithelial integrity, open tracheal systemBiological ProcessIMP (16720877)
Other Database Cross Links
NCBI Entrez Gene:38978