Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:38995
Symbol:h
Alias:8247|CG6494|Hairy|brr|dDr1|l(3)08247|l(3)rM384
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:66D10-66D10
Physical Location:8668858-8672338 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:h
P Value:2.79E-03
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014577.1NP_001014577.1NT_037436.3 range: 8668858..8672338
NM_079253.3NP_523977.2NT_037436.3 range: 8668858..8672338
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS
GO:0005634nucleusCellular ComponentIEA
GO:0016565general transcriptional repressor activityMolecular FunctionTAS (11691830)
GO:0005515protein bindingMolecular FunctionIPI (9892668)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0016566specific transcriptional repressor activityMolecular FunctionNAS
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0016044membrane organization and biogenesisBiological ProcessTAS (12593813)
GO:0008407bristle morphogenesisBiological ProcessNAS
GO:0016481negative regulation of transcriptionBiological ProcessTAS (11691830)
GO:0007460R8 cell fate commitmentBiological ProcessNAS (11880339)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (9892668)
GO:0035239tube morphogenesisBiological ProcessIMP (12526813)
GO:0035289posterior head segmentationBiological ProcessTAS (15382142)
GO:0035290trunk segmentationBiological ProcessTAS (15382142)
GO:0007435salivary gland morphogenesisBiological ProcessTAS (12742168)
GO:0007435salivary gland morphogenesisBiological ProcessIMP (12526813)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIPI (9892668)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessNAS
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (11105896)
GO:0000902cell morphogenesisBiological ProcessIMP (12526813)
GO:0007366periodic partitioning by pair rule geneBiological ProcessNAS (12717812)
GO:0007366periodic partitioning by pair rule geneBiological ProcessTAS (10611687|15382142)
GO:0007399nervous system developmentBiological ProcessTAS
GO:0007424open tracheal system developmentBiological ProcessIMP (15848387)
GO:0007431salivary gland developmentBiological ProcessTAS (12593813|14624839)
GO:0007435salivary gland morphogenesisBiological ProcessIGI (12526813)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessTAS (12119094)
Other Database Cross Links
NCBI Entrez Gene:38995
FLYBASE:FBgn0001168