| Gene Information |
| Gene ID: | | 39062 |
| Symbol: | | PGRP-LA |
| Alias: | | CG18614|CG32042|CG4361|CG4384 |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 3L |
| Genetic Location: | | 67B1-67B1 |
| Physical Location: | | 9327431-9331439 on NT_037436.3 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | PGRP-LA | | P Value: | | 2.57E-02 | | Note: | | Slow up-regulation |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005887 | integral to plasma membrane | Cellular Component | NAS | |
| GO:0016021 | integral to membrane | Cellular Component | ISS (11106397) | |
| GO:0005515 | protein binding | Molecular Function | IEA | |
| GO:0042834 | peptidoglycan binding | Molecular Function | NAS | |
| GO:0042834 | peptidoglycan binding | Molecular Function | ISS (11106397) | |
| GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity | Molecular Function | IEA | |
| GO:0016045 | detection of bacterium | Biological Process | NAS | |
| GO:0009253 | peptidoglycan catabolic process | Biological Process | NAS (11106397) | |
| GO:0009253 | peptidoglycan catabolic process | Biological Process | IEA | |
| GO:0006955 | immune response | Biological Process | ISS (11106397) | |
| GO:0006952 | defense response | Biological Process | NAS | |
| GO:0045087 | innate immune response | Biological Process | NAS (11106397) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 39062 |
| FLYBASE: | | FBgn0035975 |
