ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

aay

Alias:

0423/14|CG3705|anon-WO0172774.117

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

67B5-67B5

Physical Location:

9416352-9417903 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5723 Symbol (Name): PSPH (phosphoserine phosphatase)

Ortholog Status:

The human GeneID 5723 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		aay
P Value:		2.69E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_079277.2	NP_524001.2	NT_037436.3 range: 9416352..9417903

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0004647	phosphoserine phosphatase activity	Molecular Function	ISS
GO:0004647	phosphoserine phosphatase activity	Molecular Function	NAS (11102367)
GO:0006564	L-serine biosynthetic process	Biological Process	IEA
GO:0006564	L-serine biosynthetic process	Biological Process	NAS (11102367)
GO:0007411	axon guidance	Biological Process	IMP (11102367)
GO:0007422	peripheral nervous system development	Biological Process	TAS (11102367)