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Gene Information
Gene ID:39191
Symbol:Or67d
Alias:67d|CG14157
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:67D12-67D12
Physical Location:10266303-10267723 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Or67d
P Value:4.13E-02
Note:Acute down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140133.2NP_648390.2NT_037436.3 range: 10266303..10267723
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentISS
GO:0004984olfactory receptor activityMolecular FunctionISS
GO:0005549odorant bindingMolecular FunctionIEA
GO:0016503pheromone receptor activityMolecular FunctionIMP (17392786)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS
GO:0007608sensory perception of smellBiological ProcessISS
GO:0019236response to pheromoneBiological ProcessIMP (17392786)
Other Database Cross Links
NCBI Entrez Gene:39191
FLYBASE:FBgn0036080