ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG32103

Alias:

CG4392

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

69B4-69B5

Physical Location:

12396604-12407941 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 114789 Symbol (Name): SLC25A25 (solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25)

Ortholog Status:

The human GeneID 114789 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG32103
P Value:		3.19E-03
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005740	mitochondrial envelope	Cellular Component	ISS
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005778	peroxisomal membrane	Cellular Component	ISS
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0022857	transmembrane transporter activity	Molecular Function	ISS
GO:0006810	transport	Biological Process	ISS