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Gene Information
Gene ID:39456
Organism:Drosophila melanogaster (Fly)
Genetic Location:69E4-69E4
Physical Location:12806127-12807102 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8175    Symbol (Name): SF3A2 (splicing factor 3a, subunit 2, 66kDa)
Ortholog Status:The human GeneID 8175 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG10754
P Value:4.85E-02
Note:Transient down-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140346.1NP_648603.1NT_037436.3 range: 12806127..12807102, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005681spliceosomeCellular ComponentISS
GO:0005686snRNP U2Cellular ComponentISS (10908584)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0031202RNA splicing factor activity, transesterification mechanismMolecular FunctionISS
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessISS (10908584)
GO:0007052mitotic spindle organization and biogenesisBiological ProcessIMP (17412918)
Other Database Cross Links
NCBI Entrez Gene:39456