ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG10754

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

69E4-69E4

Physical Location:

12806127-12807102 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8175 Symbol (Name): SF3A2 (splicing factor 3a, subunit 2, 66kDa)

Ortholog Status:

The human GeneID 8175 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_140346.1	NP_648603.1	NT_037436.3 range: 12806127..12807102, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005681	spliceosome	Cellular Component	ISS
GO:0005686	snRNP U2	Cellular Component	ISS (10908584)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0031202	RNA splicing factor activity, transesterification mechanism	Molecular Function	ISS
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	ISS (10908584)
GO:0007052	mitotic spindle organization and biogenesis	Biological Process	IMP (17412918)