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Gene Information
Gene ID:39530
Symbol:CG8745
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:70C4-70C5
Physical Location:13853101-13859984 on NT_037436.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 64850    Symbol (Name): AGXT2L1 (alanine-glyoxylate aminotransferase 2-like 1)
Ortholog Status:The human GeneID 64850 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG8745
P Value:3.63E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_140408.2NP_648665.1NT_037436.3 range: 13853101..13859984, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentISS
GO:0004587ornithine-oxo-acid transaminase activityMolecular FunctionISS
GO:0008453alanine-glyoxylate transaminase activityMolecular FunctionISS
GO:0030170pyridoxal phosphate bindingMolecular FunctionIEA
GO:0019544arginine catabolic process to glutamateBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:39530
FLYBASE:FBgn0036381