ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG8745

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

70C4-70C5

Physical Location:

13853101-13859984 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 64850 Symbol (Name): AGXT2L1 (alanine-glyoxylate aminotransferase 2-like 1)

Ortholog Status:

The human GeneID 64850 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG8745
P Value:		3.63E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_140408.2	NP_648665.1	NT_037436.3 range: 13853101..13859984, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0004587	ornithine-oxo-acid transaminase activity	Molecular Function	ISS
GO:0008453	alanine-glyoxylate transaminase activity	Molecular Function	ISS
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA
GO:0019544	arginine catabolic process to glutamate	Biological Process	ISS