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Gene Information
Gene ID:39572
Symbol:nuf
Alias:CG32140|CG33991|CG7867|CIP-D2|Cy3-23|D2|EP3077|anon-D2|unnamed
Organism:Drosophila melanogaster (Fly)
Chromosome:3L
Genetic Location:70D3-70D4
Physical Location:14183976-14226349 on NT_037436.3
Gene Type:protein-coding
Human Ortholog:GeneID: 84440    Symbol (Name): RAB11FIP4 (RAB11 family interacting protein 4 (class II))
Ortholog Status:The human GeneID 84440 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:nuf
P Value:3.84E-03
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001038917.1NP_001034006.1NT_037436.3 range: 14183976..14226349
NM_001038918.1NP_001034007.1NT_037436.3 range: 14183976..14226349
NM_001038919.1NP_001034008.1NT_037436.3 range: 14183976..14226349
NM_001038920.1NP_001034009.1NT_037436.3 range: 14183976..14226349
NM_001038921.1NP_001034010.1NT_037436.3 range: 14183976..14226349
NM_001038922.1NP_001034011.1NT_037436.3 range: 14183976..14226349
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005813centrosomeCellular ComponentIDA (16137758)
GO:0005813centrosomeCellular ComponentTAS (11700298)
GO:0005875microtubule associated complexCellular ComponentISS (10908588)
GO:0008017microtubule bindingMolecular FunctionISS (10908588)
GO:0000915cytokinesis, contractile ring formationBiological ProcessNAS (11700298)
GO:0007017microtubule-based processBiological ProcessISS (10908588)
GO:0016360sensory organ precursor cell fate determinationBiological ProcessIMP (16137758)
GO:0031532actin cytoskeleton reorganizationBiological ProcessIMP (14530382)
Other Database Cross Links
NCBI Entrez Gene:39572
FLYBASE:FBgn0013718