ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

nuf

Alias:

CG32140|CG33991|CG7867|CIP-D2|Cy3-23|D2|EP3077|anon-D2|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

70D3-70D4

Physical Location:

14183976-14226349 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 84440 Symbol (Name): RAB11FIP4 (RAB11 family interacting protein 4 (class II))

Ortholog Status:

The human GeneID 84440 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		nuf
P Value:		3.84E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005813	centrosome	Cellular Component	IDA (16137758)
GO:0005813	centrosome	Cellular Component	TAS (11700298)
GO:0005875	microtubule associated complex	Cellular Component	ISS (10908588)
GO:0008017	microtubule binding	Molecular Function	ISS (10908588)
GO:0000915	cytokinesis, contractile ring formation	Biological Process	NAS (11700298)
GO:0007017	microtubule-based process	Biological Process	ISS (10908588)
GO:0016360	sensory organ precursor cell fate determination	Biological Process	IMP (16137758)
GO:0031532	actin cytoskeleton reorganization	Biological Process	IMP (14530382)