ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG7656

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

71E1-71E1

Physical Location:

15578898-15581265 on NT_037436.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54926 Symbol (Name): UBE2R2 (ubiquitin-conjugating enzyme E2R 2)

Ortholog Status:

The human GeneID 54926 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG7656
P Value:		4.00E-02
Note:		Transient down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	ISS
GO:0043687	post-translational protein modification	Biological Process	IEA
GO:0051246	regulation of protein metabolic process	Biological Process	IEA